Pathology

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  • Mayo Clinic Biobank Begins to Elucidate Bipolar Disorder

    Medscape Pathology & Lab Medicine Headlines
    7 May 2012 | 7:31 am
    Researchers hope to provide an important tool for the investigation of bipolar disorder with first analyses from the Mayo Clinic Bipolar Disorder Biobank. Medscape Medical News

  • The 2012 ASCP Workshops for Laboratory Professionals

    Pathology
    Jim Doran
    14 May 2012 | 7:15 am
    Summaries by Hopkins Pathology Employees As part of its commitment to continuing education,  the Department of Pathology sent nearly 300 employees from Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Howard County General Hospital, Suburban Hospital, and Sibley Memorial Hospital to the annual ASCP Workshops for Laboratory Professionals in Towson, Maryland, between May 1-4, 2012.  Some of our employees shared their reviews with us, and we are thankful for their generous time:    Practical Hemostasis: Laboratory Aspects of Bleeding and Thrombosis The presentation, Practical…

  • New Study Looks at Head Impacts in Youth Football

    neuropathology blog
    14 May 2012 | 10:43 pm
    We neuropathologists, and society as a whole, has spent a lot of time over the last couple of years rethinking the long-term effects brain damage causes by repeated concussive and subconcussive blows to the heads of professional and college football players. But what about the 3.5 million kids in American who play below the high school level? Dr. Peter Cummings today sent me a link to a report regarding groundbreaking research being done at Virginia Tech in which impact-measurement instruments were placed on 7 and 8-year-old football players. Data was collected on more than 750 hits to the…

  • STATLINE Issue May 11, 2012

    CAP STATLINE - Federal and State News
    11 May 2012 | 1:30 pm
    In This Issue: CAP 2012 Policy Meeting Outlines Reform Challenges, Opportunities - CAP ACO White Paper Analyzes Pathologist’s Role in Improving Quality, Reducing Costs - CAP Outlines Stage 2 Meaningful Use Concerns to ONC, CMS - Mass. Lawmakers Propose Landmark Reforms in New Bills - Palmetto Delays MolDx Requirement till June 1, 2012 - Federal Appeals Court Sets July Date to Hear Myriad Case - Keep Up with the Latest CAP Advocacy News on Twitter

  • Newspath May, 2012 - Diagnosis of Heparin-Induced Thrombocytopenia

    NewsPath - Pathology News for the Medical Community
    4 May 2012 | 9:40 am
    Heparin-induced thrombocytopenia (HIT) is a complication seen in approximately 1–3 percent of patients treated with unfractionated heparin therapy.
 
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    Pathology

  • The 2012 ASCP Workshops for Laboratory Professionals

    Jim Doran
    14 May 2012 | 7:15 am
    Summaries by Hopkins Pathology Employees As part of its commitment to continuing education,  the Department of Pathology sent nearly 300 employees from Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Howard County General Hospital, Suburban Hospital, and Sibley Memorial Hospital to the annual ASCP Workshops for Laboratory Professionals in Towson, Maryland, between May 1-4, 2012.  Some of our employees shared their reviews with us, and we are thankful for their generous time:    Practical Hemostasis: Laboratory Aspects of Bleeding and Thrombosis The presentation, Practical…

  • 2012 Virology Symposium and Meeting in Daytona Beach

    Jim Doran
    4 May 2012 | 2:16 pm
    While the recent Nor’easter brought some colder April weather to the Baltimore area, several staff of the Department were enjoying a bit warmer weather at the 28th Annual Clinical Virology Symposium and Annual Meeting of the Pan American Society for Clinical Virology in Daytona Beach. Pathology members included Linda Gluck, Amy Greer, Mike Forman, Ijeoma Ikpeama, Johanne Decoste, Estelle Piwowar-Manning, Paul Richardson, Dr. Alex Valsamakis, and Shauna Wolf. Top, from left to right, Paul Richardson, Mike Forman, Johanne Decoste, Ijeoma Ikpeama; bottom, left to right, Estelle…

  • A Lab Week Perspective: The Achievements of Our Great Labs

    Jim Doran
    20 Apr 2012 | 3:00 pm
    Lab Week is a great time to reflect on the accomplishments of our Laboratories. This year it seems our focus is more about what is left to do. So let’s take a minute to applaud ourselves for some pretty impressive achievements. CAP accreditation is number one. Every Lab participated in a very focused CAP survey administered by an experienced Mayo Clinic accreditation team. This was no simple feat. Everyone put hours of preparation to ensure that we achieved accreditation. (Way to go, Team Hopkins!) Our test menu continues to grow. We have added 11 new assays across Microbiology, the…

  • Hopkins Microbiology Heroes: The Making of Our Video for the ASCP Lab Week Contest

    Jim Doran
    12 Apr 2012 | 11:27 am
    Brandon Ellis as Bacti-Man to the rescue In my 12 years of working in the Lab, I have noticed that laboratorians tend to share a love of superheroes, be they Batman, Superwoman, or a member of the X-Men. I imagine that this is because we all fancy ourselves as bit of a superhero. To the outside world, we are just ordinary citizens like the mild-mannered Clark Kent with his oversized glasses and unassuming appearance. However, when we descend into our lairs (labs) and don our lab coats, we transform into supertechs, defenders of the patients we serve! When our fearless manager, Amelia Maters,…

  • Brazil: The Country, Its Healthcare and Clinical Pathology

    Jim Doran
    28 Mar 2012 | 2:43 pm
    Editor’s note: This blog post was written by a special guest, M. Elizabete Mendes, M.D., Ph.D., a clinical pathologist from the University of Sao Paulo, Brazil, and a CAP inspector in her country and in S.A. Dr. Mendes has been a visitor to our Department since January of 2012 and will be here until the end of March. Welcome, Dr. Mendes, and thank you for sharing with us! Dr. Mendes My name is Dr. Maria Elizabete Mendes, and I am Chief of Blood Biochemistry and Coordinator of Quality and Sustainability of Central Laboratory Division of the Hospital das Clinicas in San Paulo, Brazil. I…
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    neuropathology blog

  • New Study Looks at Head Impacts in Youth Football

    14 May 2012 | 10:43 pm
    We neuropathologists, and society as a whole, has spent a lot of time over the last couple of years rethinking the long-term effects brain damage causes by repeated concussive and subconcussive blows to the heads of professional and college football players. But what about the 3.5 million kids in American who play below the high school level? Dr. Peter Cummings today sent me a link to a report regarding groundbreaking research being done at Virginia Tech in which impact-measurement instruments were placed on 7 and 8-year-old football players. Data was collected on more than 750 hits to the…

  • "This is the single biggest change in education since the printing press."

    4 May 2012 | 7:48 pm
    Anant Agarwal, President, edXOn rare occasion, I stray from this blog's focus on clinical neuropathology to inform readers about new innovations in education. After all, we neuropathologists, almost by definition, are educators. I would therefore like to introduce a new direction in higher education that may indeed change the world. I am talking about edX, a joint venture between Harvard and MIT that will offer online learning to millions of people around the world for free. Anyone with an internet connection, whether you are a shopkeeper in Bangalore or a teenager in Modesto, will soon be…

  • Best Post of November, 2011: Neuropathology Focus of New SNO President's Address

    3 May 2012 | 9:06 am
    The next in our "Best Post of the Month" series is from November 18, 2011: Over 1400 attendees at 2011 SNO meeting in Anaheim                   Dr. Aldape discussed brain tumor biomarkers                 Same view as above, at 40XNeuropathology took center stage at the Society for Neuro-Oncology (SNO) meeting today as Dr. Kenneth D. Aldape, neuropathogist at the University of Texas MD Anderson Cancer, was introduced as the next president of the society. Dr. Aldape also delivered an…

  • Photomicrographs of last month's spinocerebellar ataxia type 6 case

    26 Apr 2012 | 2:11 pm
    A month ago, I posted gross photographs from an autopsy case of mine of a patient with spinocerebellar ataxia type 6. I am now following up with histologic images for this case. The most striking feature was the marked loss of Purkinje cells, which makes sense because SCA6 involves mutation of a calcium channel that is highly expressed on Purkinje neurons:Many remaining Purkinje neurons demonstrated degenerative changes, including mis-shapened nucleiAttenuated cerebellar granule cell layerMore Purkinje cells in bad shapeCerebellar dentate neurons also dengenerated, but not as extensively as…

  • The International Society for Frontotemporal Dementias has been founded

    20 Apr 2012 | 6:57 pm
    The following is an email sent out this week from Bernardino Ghetti, MD, neuropathologist at Indiana University:Dear Friends,Bernardino Ghetti, MDIn October 2010, I had the distinct privilege to host the 7th International Conference on Frontotemporal Dementias in Indianapolis, Indiana.  Hundreds of you from around the world participated in this exciting meeting. While the social relevance of frontotemporal dementia (FTD) is recognized, we have lacked a scientific international society devoted to the exchange of knowledge on FTD, facilitation of scientific cooperation, promotion of…
 
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    CAP STATLINE - Federal and State News

  • STATLINE Issue May 11, 2012

    11 May 2012 | 1:30 pm
    In This Issue: CAP 2012 Policy Meeting Outlines Reform Challenges, Opportunities - CAP ACO White Paper Analyzes Pathologist’s Role in Improving Quality, Reducing Costs - CAP Outlines Stage 2 Meaningful Use Concerns to ONC, CMS - Mass. Lawmakers Propose Landmark Reforms in New Bills - Palmetto Delays MolDx Requirement till June 1, 2012 - Federal Appeals Court Sets July Date to Hear Myriad Case - Keep Up with the Latest CAP Advocacy News on Twitter

  • STATLINE Issue April 26, 2012

    26 Apr 2012 | 2:22 am
    In This Issue: 2011 Practice Characteristics Survey Now Available to CAP Members - AMA Immediate Past President Wilson to Address Payment Challenges at Policy Meeting - CAP Joins AMA, Physician Groups in Questioning CMS’s Proposed Overpayment Rule - CAP Teams With CDC to Enhance Tumor Biomarker Reporting to Cancer Registries - Arizona Scope-of Practice Legislation Signed Into Law - Keep Up with the Latest CAP Advocacy News on Twitter

  • STATLINE Issue April 12, 2012

    12 Apr 2012 | 6:02 am
    In This Issue: Self-Referral Study Links Financial Self Interest, Lower Cancer Detection - Energy & Commerce Committee Criticizes FDA's RUO/IUO Draft Guidance - CMS Names 27 ACO Participants for April Launch - MedPAC Takes Aim at Overvalued PFS Services - CAP Continues Pressing CMS to Suspend Palmetto’s MolDx Program - Connecticut Genetic Counselor Bill Stalled in Committee - Congressman Price (R-GA) To Address CAP Policy Meeting Attendees - Keep Up with the Latest CAP Advocacy News on Twitter

  • STATLINE Issue April 9, 2012

    10 Apr 2012 | 8:02 am
    Special Alert: New Evidence Links Self-Referral Labs to Increased Utilization, Lower Cancer Detection Rates
 
 
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    Digital Pathology Blog

  • The New Cancer Genetics Laboratory at Baylor College of Medicine

    Kaps
    15 May 2012 | 7:00 am
    The new Cancer Genetics Laboratory at Baylor College of Medicine provides state-of-the-art clinical genetic testing in the area of cancer, both identifying cancer genes and biological markers of disease classification, prognosis and drug response. The new laboratory is a joint project of the College's Departments of Molecular and Human Genetics, Medicine – Division of Hematology/Oncology, Pediatrics – Division of Hematology/Oncology, Pathology and Immunology, the NCI-designated Dan L. Duncan Cancer Center at BCM, the Baylor College of Medicine Human Genome Sequencing Center, the Texas…

  • Visiopharm Corp Opens Office in New Jersey, United States, to Support Customers and Partners

    Kaps
    14 May 2012 | 8:01 am
    Visiopharm broadening its operations with local support in North America for growing user base.  Hoersholm, Denmark – May 14, 2012 - Visiopharm A/S, a global leader in Quantitative Digital Pathology, announced today that Visiopharm Corp will open an office in New Jersey to support partners and a rapidly growing user base in North America Visiopharm has experienced a sustained growth in the demand for Quantitative Digital Pathology research tools in North America, with a sharp increase following the recent introduction of Cloud Analysis and the APPCenter. Digital Pathology specialist Roy K.

  • Definiens Expands Functionality of Its Leading Solution for Quantitative Digital Pathology with Gene Probe Analysis

    Kaps
    10 May 2012 | 10:42 am
    Definiens Tissue Studio Now Supports the Detection of Spot-like Signals from In Situ Hybridization Assays  Munich, Germany, May 10, 2012 — Definiens®, the leading provider of image analysis and data mining solutions for quantitative digital pathology, today announced that Definiens Tissue Studio® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH. The unique combination of flexibility and ease-of-use that characterizes Definiens Tissue Studio® significantly facilitates the detection of spot-like signals originating from gene…

  • More animals found in biopsies

    Kaps
    9 May 2012 | 1:59 pm
     Every once inawhile there is an image on Facebook worth saving and sharing.  Here is one with thanks to JP for the upload.  Duodenal biopsy resembling T. Rex.  Almost as good as the duck in the prostate biopsy.   When you start seeing animals in your biopsies, its time to put the slides down for another day.

  • Sermo Reveals Results from its Real-Time Medicine™ Mobile App for Physicians

    Kaps
    9 May 2012 | 11:05 am
    Another clear example of the power of 2.0 technologies, mobile computing, hand-held communications, ability to harness collective intelligence rapidly and accurately for best decision making.  When will we in Pathology be included on the list of providers and studies included in this powerful collaboration on a broad scale? Data Shows App Speeds Treatment and Saves Lives in Urgent Care Situations Cambridge, MA - May 9, 2012 - Sermo, Inc., the largest online community in the United States exclusive to physicians, today announced results from the mobile app it launched ten months ago. Sermo…
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    Creepy Dreadful Wonderful Parasites

  • Case of the Week 208

    14 May 2012 | 10:28 am
    The following case was generously donated by MicrobeMan:The patient is a 70-year-old woman who presented with 2 weeks of fever, chills, and progressive jaundice.  She had received an orthotopic liver transplant 3 years prior.  On admission, she was noted to have acute renal failure and she was started on antibiotics for a presumed urinary tract infection.  However, peripheral blood films showed the following:Identification?

  • Case of the Week 207

    7 May 2012 | 8:58 am
    The following were an unexpected finding on anal Papanicolaou-stained pap smear from a male with papular anal lesions.  Identification? (CLICK ON IMAGES TO ENLARGE).Identification?

  • Answer to Case 207

    6 May 2012 | 10:15 am
    Answer:  Giardia intestinalis (lamblia, duodenalis) cystsThis was a very fun case because the finding of Giardia cysts was completely unexpected.  As mentioned in the history, this patient was being evaluated by an anal pap smear due to the presence of papular anal lesions which were clinically thought to be condyloma accumulatum (genital warts, caused by human papillomavirus or HPV).  Patients that have anal-receptive intercourse are at known risk for HPV associated lesions, dysplasia, and malignancy, and therefore screening for HPV-associated cytopathologic changes is…

  • Case of the Week 206

    29 Apr 2012 | 8:32 pm
    A 53 year old male presented with signs of meningitis including severe headache, nausea, vomiting, and neck stiffness.  This later progressed to seizures, neurologic abnormalities, and coma. Examination of the CSF showed elevated opening pressure, elevated protein, and eosinophilia.  The patient expired and an autopsy was performed.  The following are H&E stained sections of brain.  What is your differential diagnosis? (CLICK ON IMAGES TO ENLARGE)(400 time original magnification)(100 time original magnification) (200 time original magnification)(400 time…

  • Answer to Case 206

    28 Apr 2012 | 8:45 am
    Answer:  Eosinophilic meningitis due to Angiostrongylus cantonensisAll the respondents did a great job on getting the correct answer on this challenging case.As nicely stated by B.A.M, the identification can be made by the presence of a "syncytial, nucleated intestine, lateral chords (a bit flat in this case), smooth, thin cuticle, polymyarian musculature, and lack of alae (seen in Toxocara). Looks like an immature female, non-gravid reproductive tube present. This species rarely develops to sexual maturity in the human host."Also in the differential is Gnathostoma species, which would…
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    Lab Soft News

  • The Emerging Role of ACOs; How to Define and Reduce Unnecessary Services

    Bruce Friedman
    15 May 2012 | 7:44 am
    The need to develop an Accountable Care Organization (ACO) is one of the leading priorities of most hospital executives but there continues to be ambiguity about what an ACO is and what it is designed to accomplish (see: Hospital Executives Search for the Formula for an Accountable Care Organization; The End of Health Insurance Companies by 2020?). A recent article in The Atlantic discusses emerging healthcare models and then provides more details about ACOs (see: The 5 Mega-Trends That Are Changing the Face of Health Care). Below is an excerpt from the article about emerging models…

  • Revlimid Raises Secondary Cancer Risk for Second Primary Malignancies

    Bruce Friedman
    14 May 2012 | 9:45 am
    A new subdiscipline within oncology is getting increased attention -- survivorship (see: Cancer Survivorship, an Emerging Subdiscipline in Oncology; Cancer Survivorship and the Role of PCPs in Continuing Care of Cancer Patients). As cancer increasingly comes to be viewed as a chronic disease, more attention is being paid to the long-term medical problems of cancer survivors such as the drug damage to normal organs and also new cancers secondary to cancer therapy. Here's an account of second primary malignancy risk due to Revlimid (see: Cancer drug Revlimid (lenalidomide) raises…

  • Practice Fusion Announces a Laboratory API; the "Democratization" of Test Results

    Bruce Friedman
    11 May 2012 | 12:47 pm
    The business model for Practice Fusion, a web-based physician office EMR that can be obtained free, has been a source of great interest for me (see: Practice Fusion CEO Calls His Company the Largest EMR Provider; Practice Fusion Supported by Advertising and Owns Anonymized Data). A recent press release from the company caught my eye (see: Practice Fusion Launches API to Democratize Lab Integrations). Here's an excerpt from it: Practice Fusion, the free Electronic Medical Record (EMR) company,...announced the launch of its new lab API, which allows any laboratory in the country…

  • The Cost of Deploying an Epic EMR and the "Oreo Cookie" Analogy

    Bruce Friedman
    9 May 2012 | 11:23 am
    Mr. HIStalk recently dropped this little tidbit on us: The bond rating agency of Dartmouth-Hitchcock (NH), noting the health system’s weak operating performance, blames two factors: reduced state funding and the cost of implementing Epic. This item reinforces what I have been hearing constantly on the street, particularly from lab colleagues. Many are experiencing embargoes on lab capital spending and LIS enhancements emanating from the hospital C-suite because of the high cost of deployment of their Epic EMRs. In the past, hospital budgetary problems frequently revolved around the high…

  • Webinar Series Focusing on Digital Pathology Starts Tomorrow

    Bruce Friedman
    8 May 2012 | 6:49 am
    The Digital Pathology Association (DPA) in partnership with the Association of Pathology Informatics (API) and CAP Today will host a series of four, one-hour webinars starting tomorrow focusing on the barriers to the adoption of digital pathology. The topics to be addressed during the webinars include: a cultural and strategic perspective, regulatory issues, financial aspects of deployment, and technical issues. Each session will be moderated by Robert McGonnagle, publisher of CAP Today. Each of the four webinars will include several experts in the field who will deliver short and…
 
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    Digital Pathology Blog via MedWorm.com

  • The New Cancer Genetics Laboratory at Baylor College of Medicine

    14 May 2012 | 10:00 pm
    The new Cancer Genetics Laboratory at Baylor College of Medicine provides state-of-the-art clinical genetic testing in the area of cancer, both identifying cancer genes and biological markers of disease classification, prognosis and drug response. The new laboratory is a joint project of the College's Departments of Molecular and Human Genetics, Medicine – Division of Hematology/Oncology, Pediatrics – Division of Hematology/Oncology, Pathology and Immunology, the NCI-designated Dan L. Duncan Cancer Center at BCM, the Baylor College of Medicine Human Genome Sequencing Center, the Texas…

  • Visiopharm Corp Opens Office in New Jersey, United States, to Support Customers and Partners

    13 May 2012 | 10:00 pm
    Visiopharm broadening its operations with local support in North America for growing user base.  Hoersholm, Denmark – May 14, 2012 - Visiopharm A/S, a global leader in Quantitative Digital Pathology, announced today that Visiopharm Corp will open an office in New Jersey to support partners and a rapidly growing user base in North America Visiopharm has experienced a sustained growth in the demand for Quantitative Digital Pathology research tools in North America, with a sharp increase following the recent introduction of Cloud Analysis and the APPCenter. Digital Pathology specialist Roy K.

  • Definiens Expands Functionality of Its Leading Solution for Quantitative Digital Pathology with Gene Probe Analysis

    9 May 2012 | 10:00 pm
    Definiens Tissue Studio Now Supports the Detection of Spot-like Signals from In Situ Hybridization Assays  Munich, Germany, May 10, 2012 — Definiens®, the leading provider of image analysis and data mining solutions for quantitative digital pathology, today announced that Definiens Tissue Studio® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH. The unique combination of flexibility and ease-of-use that characterizes Definiens Tissue Studio® significantly facilitates the detection of spot-like signals originating from gene…

  • CAP ’12 Brings You Special Transformation Programming

    8 May 2012 | 10:00 pm
    Register Now Join us for breakfast and an early morning of free programming (for residents and daily, global, or networking pass registrants) specifically designed to provide you with information you can use now and in the future to continue your transformation! Tuesday, September 11 TP200  Breakfast Workshop – Digital Pathology: Making a Difference in Your Practice   6:30–7:45 amCME/CE Not Applicable This workshop focuses on digital pathology, highlighting the work of the CAP Transformation Program Office Module 4 Emerging Technology team. This session will describe current and…

  • Sermo Reveals Results from its Real-Time Medicine™ Mobile App for Physicians

    8 May 2012 | 10:00 pm
    Another clear example of the power of 2.0 technologies, mobile computing, hand-held communications, ability to harness collective intelligence rapidly and accurately for best decision making.  When will we in Pathology be included on the list of providers and studies included in this powerful collaboration on a broad scale? Data Shows App Speeds Treatment and Saves Lives in Urgent Care Situations Cambridge, MA - May 9, 2012 - Sermo, Inc., the largest online community in the United States exclusive to physicians, today announced results from the mobile app it launched ten months ago. Sermo…
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    Diagnostic Pathology - Latest Articles

  • Primary central nervous system plasmablastic lymphoma presenting in human immunodeficiency virus-negative but Epstein-Barr virus-positive patient: A case report

    Li Ying Zhang
    7 May 2012 | 7:00 pm
    We report a 32-year-old Outer Mongolian man, with plasmablastic lymphoma (PBL)primarily occured in the central nervous system and diagnosed by surgical resection. Thispatient appeared headache and Magnetic resonance imaging (MRI) showed multiple lesionsin the right cerebral hemisphere including the right frontal-parietal lobe and right basalganglia and the left cerebellum, he was diagnosed as lymphoma by stereotactic biopsy inJanuary 2009 in local hospital, and was given radiotherapy 33 times after the biopsy. Thepatient was admitted to The Military General Hospital of Beijing PLA., Beijing,…

  • Renal infarction due to polyarteritis nodosa in a patient with angioimmunoblastic T-cell lymphoma: a case report and a brief review of the literature

    Maria Raffaella Ambrosio
    7 May 2012 | 7:00 pm
    Angioimmunoblastic T-cell lymphoma (AITL) is one of the most common subtypes of peripheral T-cell lymphoma (15-20% of all cases), accounting for approximately 1-2% of all non-Hodgkin lymphomas. It often presents autoimmune phenomena including hemolytic anemia, thrombocytopenia, glomerulonephrities and circulating immune complexes (CIC). Polyarteritis nodosa (PAN) is an autoimmune disease characterized by necrotizing vasculitis of medium vessels, which rarely develops in association with hematological malignant disorders. Herein we report the case of a male patient with AITL who had a renal…

  • Sporadic Hemangioblastoma of the Kidney: a rare renal tumor

    Yang Liu
    30 Apr 2012 | 7:00 pm
    Hemangioblastoma is a benign and morphologically distinctive tumor that can occursporadically or in association with von Hippel-Lindau disease in approximately 25 % of thecases, and which involves the central nervous system in the majority of the cases. Rareoccurrences of hemangioblastoma in peripheral nerves and extraneural tissues have beenreported. This report describes one case of sporadic renal hemangioblastoma happened in a16-year-old Chinese female patient, presenting with hematuria, and low back pain.Histologically, the tumors were circumscribed, and composed of sheets of large…

  • Introduction of virtual microscopy in routine surgical pathology - a hypothesis and personal view from Europe

    Klaus Kayser
    29 Apr 2012 | 7:00 pm
    The technology of whole image acquisition from histological glass slides (Virtual slides,(VS)) and its associated software such as image storage, viewers, and virtual microscopy(VM), has matured in the recent years. There is an ongoing discussion whether to introduceVM into routine diagnostic surgical pathology (tissue-based diagnosis) or not, and if these areto be introduced how best to do this. The discussion also centres around how to substantiallydefine the mandatory standards and working conditions related to introducing VM. Thisarticle briefly describes some hypotheses alongside our…

  • Serum peptidome patterns of breast cancer based on magnetic bead separation and mass spectrometry analysis

    Nai-Jun Fan
    19 Apr 2012 | 7:00 pm
    Background: Breast cancer is one of the most common cancers in the world, and the identification ofbiomarkers for the early detection of breast cancer is a relevant target. The present study aimsto determine serum peptidome patterns for screening of breast cancer. Methods: The present work focused on the serum proteomic analysis of 36 healthy volunteers and 37breast cancer patients using a ClinProt Kit combined with mass spectrometry (MS). Thisapproach allows the determination of peptidome patterns that are able to differentiate thestudied populations. An independent group of sera (36 healthy…
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    The Daily Sign-Out

  • Abstracts and Posters Accepted Now for Pathology Visions 2012

    Mark D. Pool, M.D.
    15 May 2012 | 7:30 am
    As a courtesy to the Digital Pathology Association, I am passing along this information regarding the 2012 Pathology Visions conference in Baltimore, Maryland from October 28-31, 2012. Please consider submitting an abstract for oral presentation and/or poster presentation. This is...

  • New proposal for histological grading in colorectal carcinoma

    Mark D. Pool, M.D.
    10 May 2012 | 7:40 am
    I find it surprising that histological grading for two of the most common adult malignancies--colon and lung--lacks any kind of consensus criteria for grading elements let alone clinical validation as a prognostic marker. I have previously blogged on proposals for...

  • The new IASLC/ATS/ERS Lung Adencarcinoma Classification is a Stage-Independent Predictor of Survival

    Mark D. Pool, M.D.
    8 May 2012 | 8:00 am
    I blogged on this new classification over a year ago when it was first published, but now papers are rolling out showing its utility. My take on this recent paper below is that it confirms the idea of histologically grading...

  • New biomarkers for mesothelioma

    Mark D. Pool, M.D.
    8 May 2012 | 7:45 am
    Today is a first for this blog--a guest post! I recently was contacted by Danielle DiPietro, National Awareness Director for the Mesothelioma Center at Asbestos.com to see if I might be interested in a guest blog. What follows is a...

  • The new paternalism in American medicine

    Mark D. Pool, M.D.
    7 May 2012 | 8:00 am
    It has taken me awhile to get to this article by Hartzband and Groopman, "Rise of the Medical Expertocracy," from the March 31, 2011 Wall Street Journal. If you happened to miss it, it is quite thought-provoking. Whether you are...
 
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    InCyte Pathology's Blog

  • Top Five Most Common Pap Smear Coding Errors

    incytepathology
    8 May 2012 | 10:56 am
    Changes over the years in coding guidelines have affected how we should code and bill pathology specimens.  Not all offices may be aware of these changes or may interpret their application differently.  The InCyte Pathology coding experts will attempt to provide clarity for the Top 5 Most Common Pap Smear Coding Errors we see in our practice.   #1) Diagnostic vs. Screening.  To help you determine if a Pap smear was performed for diagnostic or screening purposes, here are a few tips.  A diagnostic code should be used where there are any signs or symptoms of disease. A Pap smear is…

  • New Cervical Cancer Screening Guidelines – Should Not Lessen the Importance of the Annual Exam

    incytepathology
    30 Apr 2012 | 11:10 am
    Dr. Felix Martinez, Jr. The experts have weighed in and now have spoken in unison: “less is more.” In March 2012, four major organizations – preventative, professional and governmental – jointly issued new guidelines for cervical cancer screening. The authors of the new guidelines reviewed thousands of trials and different types of studies performed all over the world1. The guidelines come from the United States Preventative Services Task Force (USPSTF) and a collaboration between the American Cancer Society (ACS), American Society of Colposcopy and Cervical Pathology (ASCCP),…

  • BRAF Mutation in Metastatic Melanoma

    incytepathology
    10 Apr 2012 | 4:59 pm
    David C. Hoak, M.D. Until recently, a diagnosis of metastatic melanoma was often accompanied with a poor prognosis for treatment. Very little success had been achieved by a regimen of existing therapies until the discovery of the significant role played by the gene encoding kinase B-Rapidly Accelerating Fibrosarcoma (BRAF) in the growth and spread of this disease. This bleak outlook has brightened with new advancements in treatments for patients with BRAF V600E mutation-positive unresectable or metastatic melanoma. Metastatic melanoma has been a highly invasive, fast-growing malignancy with…

  • The Origin of Ovarian Carcinoma: Why the Debate Matters?

    incytepathology
    30 Mar 2012 | 1:21 pm
    Sanjay Logani, M.D. Ovarian cancer is the fifth deadliest cancer among American women. Unfortunately, despite all of the advances in early detection and improved cancer screening, ovarian cancer still has a disproportionately high mortality rate, which can be directly attributed to the difficulty diagnosing the disease in its early stages. As a result, most ovarian cancer patients are diagnosed too late with advanced-stage disease. Early detection of serous ovarian cancer would save the lives of many women, but there is no reliable screening test that has the sensitivity or the specificity to…

  • InCyte Pathologists Included in 2012 Best Doctors List

    incytepathology
    22 Mar 2012 | 4:12 pm
    David C. Hoak, M.D. Thomas J. Allerding, M.D. Thomas J. Allerding, M.D. and David C. Hoak, M.D. were recently selected by their peers for inclusion in the Best Doctors 2012 list in the field of Pathology.  Dr. Allerding is past president of the Spokane County Medical Society, a past trustee of the Washington State Medical Association and has been with InCyte Pathology since 1983. Dr. Hoak is currently serving as Chief Medical Director and has been with InCyte Pathology since 1993.  He has been the Medical Director of the Laboratory at Sacred Heart Medical Center and Kadlec Medical Center,…
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    Digital Pathology Insights

  • Webinar Postponed: Aperio and Definiens Present the Full Spectrum of Applications for Quantitative ePathology

    Florian Leiss
    14 May 2012 | 2:58 am
    This webinar will highlight the benefits of the integration between Aperio’s eSlide Manager and Definiens Tissue Studio. Dr. Hartmann will introduce Definiens Tissue Studio and demonstrate functionality supporting the automated analysis of in situ hybridization assays, including SISH, CISH, and dual-ISH. The webinar will be rescheduled and the new date will be announced shortly. We apologize for any inconvenience.

  • Definiens Expands Functionality of Its Leading Solution for Quantitative Digital Pathology with Gene Probe Analysis

    Florian Leiss
    10 May 2012 | 9:08 am
    Definiens Tissue Studio Now Supports the Detection of Spot-like Signals from In Situ Hybridization Assays Munich, Germany, May 10, 2012 — Definiens®, the leading provider of image analysis and data mining solutions for quantitative digital pathology, today announced that Definiens Tissue Studio® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH. The unique combination of flexibility and ease-of-use that characterizes Definiens Tissue Studio® significantly facilitates the detection of spot-like signals originating from gene…

  • DPA Webinar Series: “Barriers to the Adoption of Digital Pathology”

    Florian Leiss
    8 May 2012 | 3:32 am
    The Digital Pathology Association (DPA) in partnership with the Association of Pathology Informatics and CAP Today will host a series of four, one-hour webinars in 2012 focusing on the barriers to adoption of digital pathology. The topics to be addressed during the webinars include: a cultural and strategic perspective, regulatory issues, financial aspects of deployment, and technical considerations. Each session will be moderated by Robert McGonnagle, publisher of CAP Today. Each of the four webinar sessions will include several experts in the field who will deliver short & focused…

  • Definiens is a Finalist for the 2012 Red Herring Top 100 Europe Award

    Florian Leiss
    30 Apr 2012 | 2:48 am
    Munich, Germany, April 30, 2012 — Definiens®, the leading provider of image analysis and data mining solutions for quantitative digital pathology, announced today it has been selected as a Finalist for Red Herring’s Top 100 Europe award, a prestigious list honoring the year’s most promising private technology ventures from the European business region. The Red Herring editorial team selected the most innovative companies from a pool of hundreds from across Europe. The nominees are evaluated on both quantitative and qualitative criteria, such as financial performance, technology…

  • Free Webinar Series: Quantitative Digital Pathology Made Easy

    Florian Leiss
    24 Apr 2012 | 8:36 am
    Attend the upcoming webinars in our “Quantitative Digital Pathology Made Easy” series. This Thursday, Mark Lloyd from the Moffitt Cancer Center will present his exciting research into how single-cell features elucidate spatially heterogeneous morphotypes in histological tissue sections. Next week, Martin Baatz from Definiens will emphasize that automated image analysis yields substantial productivity gains for pre-clinical safety studies. We would be delighted to welcome you on the webinars and to answer your questions. Best regards, The Definiens team     Single-Cell…
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